Explore the Agenda
7:30 am Check In, Coffee & Networking
Workshop A
8:30 am Designing Antibody-Based Degraders to Overcome ADC Limitations & Unlock New Therapeutic Opportunities for TPD
As antibody-derived degraders emerge as a powerful alternative to small molecules, this workshop will teach you how to engineer and optimise these biologics to unlock new extracellular degradation strategies.
We will cover:
- Comparing antibody-based degraders with PROTACs and molecular glues to highlight expanded E3 ligase use and tissue-specific targeting enabled by Laigo’s platform
- Leveraging NANOBODY® VHH and antibody engineering to enable precise target engagement and novel extracellular degradation strategies
- Elucidating biodistribution and internalisation pathways to ensure targeted delivery of DACs and minimise off-target effects across tissues and cell types
This workshop is ideal for scientists exploring how antibody-derived scaffolds can extend targeted protein degradation beyond intracellular targets.
10:30 am Morning Break & Networking
Workshop B
11:00 am Harnessing Autophagy & Molecular Glue Strategies to Enable Degrader Therapeutics in Neurodegeneration & Complex Disease Areas
As degraders expand into non-oncology indications, this workshop will show you how autophagy-mediated and molecular glue approaches are being applied to tackle neurodegenerative diseases and other biologically complex conditions.
We will cover:
- Demonstrating the role of molecular glue–mediated stabilisation in restoring proteostasis in tau, α-synuclein, and LRRK2-driven neurodegeneration
- Showcasing the bimodal mechanism-of-action of the AUTOTAC platform in targeted protein degradation and selective autophagy activation, with a focus on translation of basic research findings for drug discovery
- Autophagy-mediated clearance of pathological protein aggregates in neuronal models of neurodegenerative diseases
This workshop is ideal for biologists and chemists exploring TPD approaches in non-oncology settings, from target selection to translation.
New Data
1:00 pm Networking Lunch
Workshop C
2:00 pm Identifying Tractable Targets for Molecular Glues & Moving Beyond Cereblon Chemistry to Recruit Neo-Substrates Against More Indications
As molecular glue development moves beyond cereblon, this workshop will teach you how to identify tractable ligase–substrate pairs and validate glue activity to unlock new degradation strategies.
We will cover:
- Developing molecular glue discovery platforms to accelerate identification of novel degraders beyond cereblon
- Modelling and validating new ligases to enable degradation of intrinsically disordered proteins (IDPs)
- Applying genetic and phenotypic screening approaches to pinpoint ligases, map degrons, and confirm true glue activity
- Exploring alternative ligase recruitment strategies to overcome G-loop dependency and bind novel neo-substrates
This workshop is ideal for discovery biologists and medicinal chemists expanding
molecular glue development beyond cereblon
New Data