• Integrating structural biology, bioinformatics and chemoinformatics to rationally design Targeted Glues™ that achieve selective degradation across diverse targets
• Demonstrating mechanistic insights and preclinical progress of SMART T degraders employing distinct E3 ligases to validate platform versatility
• Applying structure-guided principles to accelerate translation of novel glue–ligase combinations from discovery to clinical readiness

Noval Ligase