BacPROTAC-induced degradation of ClpC1 as a new strategy against drug-resistant mycobacteria
Time: 3:30 pm
day: Pre-Conference Day
Details:
- Hijacking the mycobacterial protease ClpC1:ClpP1P2 offers unique opportunities to overcome antimicrobial resistance
- Outlining the development of natural product-inspired degraders, “BacPROTACs” that bind to the substrate receptor of the ClpC1:ClpP1P2 protease, priming neo-substrates for degradation.
- Reviewing the degradation and anti-mycobacterial properties of homo- BacPROTACs that induce the degradation of ClpC1 in Mycobacterium tuberculosis
