Cellular Parameters of PROTAC Selectivity

Time: 2:00 pm
day: Day 1 PM - Stream A


  • Aurora kinase A (AURKA) is a cellular target that exists in functionally distinct subcellular pools
  • Cereblon-directed PROTACs bring about targeted protein degradation (TPD) of AURKA but the different subcellular pools of the target are not equally degraded
  • Our experiments aim to identify the cellular parameters influencing target selection and degradation