Charting the Evolution & Future of Targeted Protein Degradation: From Fundamental Mechanisms to Translational Impact

  • Reflecting on the evolution of the TPD field, from early degrader design principles to today’s landscape of molecular glues and emerging proximity modalities
  • Showcasing latest advances from the Ciulli Lab in mechanistic understanding and chemical biology of degraders, including unpublished data on previously undruggable targets and ternary complex formation
  • Highlighting collaborative academic and industry consortia tackling grand challenges in paediatric cancers and neurodegenerative diseases
  • Exploring the translational frontier, from spin-out innovation and pharma partnerships to future directions that will define the next generation of proximity-based therapeutics

New Data