Charting the Evolution & Future of Targeted Protein Degradation: From Fundamental Mechanisms to Translational Impact
- Reflecting on the evolution of the TPD field, from early degrader design principles to today’s landscape of molecular glues and emerging proximity modalities
- Showcasing latest advances from the Ciulli Lab in mechanistic understanding and chemical biology of degraders, including unpublished data on previously undruggable targets and ternary complex formation
- Highlighting collaborative academic and industry consortia tackling grand challenges in paediatric cancers and neurodegenerative diseases
- Exploring the translational frontier, from spin-out innovation and pharma partnerships to future directions that will define the next generation of proximity-based therapeutics
New Data