Chimeric Peptide Degraders for Protein Knockdowns in Gram Negative Bacteria

Time: 3:30 pm
day: Day One


  • Targeted protein degradation in Gram negative bacteria must use direct protease recruitment due to the absence of proteolysis-targeting posttranslational
  • The unfoldase ClpX is a conserved component in proteolytic machinery of most bacteria that may be used to anchor bacterial degraders
  • Chimeric peptides recruiting ClpX to degrade essential proteins show antimicrobial activity in Escherichia coli correlated with depletion of the target proteins