Chimeric Peptide Degraders for Protein Knockdowns in Gram Negative Bacteria
Time: 3:30 pm
day: Day One
Details:
- Targeted protein degradation in Gram negative bacteria must use direct protease recruitment due to the absence of proteolysis-targeting posttranslational
modifications - The unfoldase ClpX is a conserved component in proteolytic machinery of most bacteria that may be used to anchor bacterial degraders
- Chimeric peptides recruiting ClpX to degrade essential proteins show antimicrobial activity in Escherichia coli correlated with depletion of the target proteins
