Investigating Molecular Glue Degrader Mechanism of Action Through Orthogonal Genetic Screening, Biophysical & Structural Analyses

• Orthogonal screening approaches identify a novel glue mechanism and expand degrader strategies
• Subtle chemical modifications allow for modular glue engagement
• Tunable degradation systems for advancing next-generation targeted therapies with greater adaptability and resistance resilience

Speakers:

Dmitri Segal

Postdoctoral Fellow

AITHYRA Institute for Biomedical AI