Developing Novel Extracellular Degrader Formats to Overcome Biodistribution & Internalisation Challenges in Complex Tissues
- Leveraging proteomics to identify compatible target–internalisation driver pairs that support tissue-specific degradation and therapeutic precision
- Exploring non-proteasomal degradation pathways to expand modality options and reduce toxicity associated with intracellular accumulation
- Integrating sweeping mechanisms to recycle biologics while degrading targets to improve durability and reduce off-target degradation