Developing Novel Extracellular Degrader Formats to Overcome Biodistribution & Internalisation Challenges in Complex Tissues

• Leveraging proteomics to identify compatible target–internalisation driver pairs that support tissue-specific degradation and therapeutic precision
• Exploring non-proteasomal degradation pathways to expand modality options and reduce toxicity associated with intracellular accumulation
• Integrating sweeping mechanisms to recycle biologics while degrading targets to improve durability and reduce off-target degradation

Speakers:

Simon Glerup

CSO

Draupnir Bio