Discovery of a Novel Functional E3 Binder Through PROTEINi-Enabled Screening

Time: 12:00 pm
day: Day 1 AM - Stream A


  • The development of novel degraders with appropriate drug development properties requires a systematic functional deconvolution of the E3 ligase space
  • The PROTEINi screening developed by PhoreMost has been used to uncover novel phenotypically active peptide ligands from which to build drug discovery pipelines
  • In this seminar, we will show how we have used to thisto find both novel lead functional small molecule E3 binders, and fully active heterobifunctional peptide degraders