Fireside Chat: Navigating Phenotypic Screening & Biology-First Strategies for Novel Induced Proximity Therapeutics
- Evaluating the strengths and limitations of phenotypic screening for discovering novel proximity therapeutics
- Comparing biology-first versus chemistry-first approaches to proximity drug discovery
- Leveraging biology-first strategies to unlock non-degrader modalities such as stabilisers, modulators and activators by anchoring discovery in disease-relevant phenotypes and mechanistic pathways
- Addressing the complexity of biological assay readouts in non-oncology indications and discussing how inflammation, neurodegeneration and other areas challenge traditional screening assays