From Design to Application: A CRBN Molecular Glue Library Derived from In-House and Literature-Validated CRBN Binders

• A systematic exploration of the chemical space of CRBN-binding scaffolds (300 compounds synthesized and tested) 
• SAR insights and highlighting representative, structurally novel, and effective binders.
• An overview of HitChem’s CRBN molecular glue library design strategy and HTS case studies on multiple targets

Speakers:

Hongbo Zhang

Chief Scientific Officer & Head of Drug Discovery Service

HitChem