Discovery of Molecular Glue Degraders via Phenotypic Chemical Screens

Time: 9:40 am
day: Day One


  • Coupling genome-scale CRISPR screens with degrader treatment identifies a comprehensive network of cellular effectors required for efficient TPD
  • Development of isogenic, hyponeddylated cell line models based on this effector network empowered differential chemical screening to identify novel and molecular glue degraders
  • Multi-omics target identification led us to identify novel degraders of Cyclin K that operate via a unique mechanism that is independent of a dedicated substrate receptor