As molecular glue development moves beyond cereblon, this workshop will teach you how to identify tractable ligase–substrate pairs and validate glue activity to unlock new degradation strategies.

We will cover:

• Developing molecular glue discovery platforms to accelerate identification of novel degraders beyond cereblon
• Modelling and validating new ligases to enable degradation of intrinsically disordered proteins (IDPs)
• Applying genetic and phenotypic screening approaches to pinpoint ligases, map degrons, and confirm true glue activity
• Exploring alternative ligase recruitment strategies to overcome G-loop dependency and bind novel neo-substrates

This workshop is ideal for discovery biologists and medicinal chemists expanding

molecular glue development beyond cereblon

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