Modelling Molecular Glue Mechanisms to Enable Reliable Discovery & Biochemical Characterisation
- Building quantitative models that describe ternary complex behaviour and support mechanistic interpretation of molecular glue function in early discovery
- Optimising biochemical assay design and conditions to maximise the likelihood of identifying novel molecular glue candidates during screening.
- Integrating modelling outputs and in vitro characterisation workflows into optimisation campaigns to derive the key thermodynamic parameters of the molecular glue candidates