Modelling Molecular Glue Mechanisms to Enable Reliable Discovery & Biochemical Characterisation

• Building quantitative models that describe ternary complex behaviour and support mechanistic interpretation of molecular glue function in early discovery
• Optimising biochemical assay design and conditions to maximise the likelihood of identifying novel molecular glue candidates during screening.
• Integrating modelling outputs and in vitro characterisation workflows into optimisation campaigns to derive the key thermodynamic parameters of the molecular glue candidates

Speakers:

Maxime Couturier

Senior Research Scientist (Assay, Profiling and Cells Sciences)

AstraZeneca