Enabling Therapeutic Degradation of Undruggable Targets

Time: 11:30 am
day: Day One


  • DNA-encoded library (DEL) technology is uniquely enabling for development of the next generation of PROTAC therapeutics: DEL can yield ligands with the desired attributes for compelling but undruggable targets
  • DEL is equally powerful at generating adequate ligands for recruiting E3 ligases via PROTACs
  • Generation and characterisation of potent SHP2 PROTACs; comparison with allosteric inhibitors