Targeted Degradation of SARS-CoV-2 Proteases for Antiviral Therapy
Time: 10:30 am
day: Pre-Conference Day
- Targeted protein degradation of viral proteins has distinct advantages over the traditional drugs, chief being lack resistance.
- SARS-CoV2 genome encodes two proteases, 3 CLpro (NSP3) and PLpro (NSP5), both are essential genes for the virus replication.
- Progenra has developed PROTACs against SARS-CoV2 PLpro. The PLpro PROTACs are potent degraders of the protein and demonstrate superior antiviral properties as compared to parent PLpro inhibitors.
- Mechanisms of the PLpro role in SARS-CoV2 propagation and PROTACs will be discussed