Adam Bond PhD

Adam Bond PhD

Company: University of Dundee

Job title: Student Centre for Targeted Protein Degradation (CeTPD)


Amide-to-Ester Substitution as a Strategy for Optimising PROTAC Permeability & Cellular Activity 11:30 am

*Remote Presentation*  Bifunctional PROTAC degraders belong to “beyond Rule of 5” chemical space, and criteria for predicting their drug-like properties are underdeveloped A simple, yet unconventional, amide-to-ester substitution in BET degraders leads to increased cellular activity Increases in PROTAC activity is due to increases in cellular permeability and not due to enhancement of ternary complex…Read more

day: Day 2 AM - Stream B

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