Benika Pinch

Benika Pinch

Company: Novartis Institutes for BioMedical Research

Job title: Principal Scientist

Seminars:

A Strategy to Assess the Cellular Activity of E3 Ligase Components against Neo-Substrates Using Electrophilic Probes 12:00 pm

COFFEE (Covalent Functionalization Followed by E3 Electroporation) tests neo-substrate degradation by chemically modified E3 ligase components Recombinant E3s are labelled with maleimide functionalized neo-substrate ligands, and then electroporated into cells Proof-of-concept degradation by electroporated JQ1- or dasatinib-labeled VHL. Discovery that SPSB2 and SKP1 can be redirected to degrade tyrosine kinasesRead more

day: Day 1 AM - Stream A

© Copyright 2018 Hanson Wade | Design and site by Event Engine | Hanson Wade Limited is registered in England & Wales, number 06752216.
Registered Office: Suite A, 6 Honduras Street, London EC1Y 0TH.