Giovanni Spagnolli
Chief Technology Officer & Co-founder Sibylla Biotech srl
Seminars
Thursday 12th March 2026
Targeting Protein Folding Intermediates for Degradation: an Integrated Platform with Multi-Target Applications
1:20 pm
- Introduction of Sibylla’s PPI-FIT platform for identifying small molecules that induce target degradation by interfering with protein folding pathways.
- Description of the integrated workflow combining computational biophysics, medicinal chemistry, and artificial intelligence to discover folding-interfering molecules.
- Application of the platform across multiple targets, highlighting the Cyclin D1 lead program and expanding to additional oncological and non-oncological case studies.
