Juan Carlos Mobarec
Seminars
Wednesday 11th March 2026
Navigating Phenotypic Screening & Biology-First Strategies for Novel Induced Proximity Therapeutics
4:15 pm
- Assessing the strengths, limitations and translational value of phenotypic screening for discovering novel proximity therapeutics
- Comparing biology-first and chemistry-first approaches, and how each guides hit identification, mechanistic validation and modality selection
- Exploring how biology-first strategies and complex disease-relevant assays can unlock non-degrader modalities such as stabilisers, modulators and activators
- Integrating AI-driven modelling and in silico cooperativity prediction with phenotypic and mechanistic workflows to accelerate molecular glue discovery
