Maria Górna

Maria Górna

Company: University of Warsaw

Job title: Principle Investigator, Structural Biology Group


Chimeric Peptide Degraders for Protein Knockdowns in Gram Negative Bacteria 3:30 pm

Targeted protein degradation in Gram negative bacteria must use direct protease recruitment due to the absence of proteolysis-targeting posttranslational modifications The unfoldase ClpX is a conserved component in proteolytic machinery of most bacteria that may be used to anchor bacterial degraders Chimeric peptides recruiting ClpX to degrade essential proteins show antimicrobial activity in Escherichia coli…Read more

day: Day One

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