Martin Stahl

As molecular glue development moves beyond cereblon, this workshop will teach you how to identify tractable ligase–substrate pairs and validate glue activity to unlock new degradation strategies.

We will cover:

• Developing molecular glue discovery platforms to accelerate identification of novel degraders beyond cereblon
• Modelling and validating new ligases to enable degradation of intrinsically disordered proteins (IDPs)
• Applying genetic and phenotypic screening approaches to pinpoint ligases, map degrons, and confirm true glue activity
• Exploring alternative ligase recruitment strategies to overcome G-loop dependency and bind novel neo-substrates

This workshop is ideal for discovery biologists and medicinal chemists expanding

molecular glue development beyond cereblon

New Data