Nello Mainolfi

Nello Mainolfi

Company: Kymera Therapeutics

Job title: Founder, President & Chief Scientific Officer


Before founding Kymera, Nello was head of drug discovery at Raze Therapeutics (an Atlas portfolio company) where he helped develop first in class molecules against novel cancer metabolism targets with implications in both oncology and immuno-metabolism. Nello started his drug discovery career in the global discovery chemistry group at the Novartis Institutes for Biomedical Research, where he contributed and in most cases led teams to the identification of more than 10 compounds that have entered preclinical and clinical development across a series of disease areas. Notably first in class small molecules inhibitors of several complement proteins for inflammation and ocular diseases. While at Novartis he also championed new technologies such as using fragment-based drug discovery as a core strategy to deliver multiple development candidates. Nello has authored >40 papers and patents and has written reviews in the areas of medicinal chemistry and drug discovery. Nello was trained at Imperial College, University of London and The Scripps Research Institute in California.


Panel Discussion 1:50 pm

What are the similarities and differences between traditional drug discovery and TPD during the pre-clinical discovery efforts and clinical studies? Knowing what we know now, if you were to build a team and a strategy on TPD discovery and development from scratch, what changes would you make if any? What are the key translational bottlenecks…Read more

day: Day Two

Targeted Protein Degradation Beyond Oncology 9:00 am

Advancing understanding and impact of TPD beyond existing E3 ligases What’s needed to build programs beyond Oncology? IRAK4 degrader programs in immunologyRead more

day: Day Two

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