Peggy Scherle

Company: Prelude Therapeutics​

Job title: Chief Scientific Officer

Seminars:

Bridging Pharmacokinetics & Pharmacodynamics to Enhance the Pre-Clinical Efficacy of Degrader-Loaded ADCs Targeting SMARCA &CDK9 for Drug Development Optimisation 11:15 am

Exploring the pharmacokinetic and pharmacodynamic challenges unique to SMARCA and CDK9 targets, focusing on degradation thresholds required to maximise therapeutic efficacy Examining the role of linker stability and release mechanisms in ADCs carrying degrader payloads, aiming to achieve controlled, targeted delivery of degraders to tumour cells Assessing how linker and payload characteristics influence absorption, distribution,…Read more

day: Day 1, Track 2, AM