Thomas Hayhow
Company: AstraZeneca
Job title: Medicinal Chemist
Seminars:
Discussion/Q&A 3:00 pm
day: Day One
A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs 1:30 pm
CRBN binders have some of the best physicochemical properties to make PROTACs with that lie within the extended rule of five properties Existing methods to synthesise lenalidomide-like CRBN binders that vary the group to the isoindolinone require inserting chemical diversity at the first synthetic step We developed a robust Buchwald-Hartwig methodology to introduce a wide…Read more
day: Day One