Thomas Hayhow

Thomas Hayhow

Company: AstraZeneca

Job title: Medicinal Chemist

Seminars:

Discussion/Q&A 3:00 pm

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day: Day One

A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs 1:30 pm

CRBN binders have some of the best physicochemical properties to make PROTACs with that lie within the extended rule of five properties Existing methods to synthesise lenalidomide-like CRBN binders that vary the group to the isoindolinone require inserting chemical diversity at the first synthetic step We developed a robust Buchwald-Hartwig methodology to introduce a wide…Read more

day: Day One

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