Zoran Rankovic
Director & Professor - Chemical Biology & Protein Degradation, Center for Protein Degradation Institute of Cancer Research
Seminars
Tuesday 10th March 2026
Identifying Tractable Targets for Molecular Glues & Moving Beyond Cereblon Chemistry to Recruit Neo-Substrates Against More Indications
2:00 pm
As molecular glue development moves beyond cereblon, this workshop will teach you how to identify tractable ligase–substrate pairs and validate glue activity to unlock new degradation strategies.
We will cover:
- Developing molecular glue discovery platforms to accelerate identification of novel degraders beyond cereblon
- Modelling and validating new ligases to enable degradation of intrinsically disordered proteins (IDPs)
- Applying genetic and phenotypic screening approaches to pinpoint ligases, map degrons, and confirm true glue activity
- Exploring alternative ligase recruitment strategies to overcome G-loop dependency and bind novel neo-substrates
This workshop is ideal for discovery biologists and medicinal chemists expanding
molecular glue development beyond cereblon
New Data
Wednesday 11th March 2026
Fireside Chat: Navigating Phenotypic Screening & Biology-First Strategies for Novel Induced Proximity Therapeutics
12:00 pm
- Evaluating the strengths and limitations of phenotypic screening for discovering novel proximity therapeutics
- Comparing biology-first versus chemistry-first approaches to proximity drug discovery
- Leveraging biology-first strategies to unlock non-degrader modalities such as stabilisers, modulators and activators by anchoring discovery in disease-relevant phenotypes and mechanistic pathways
- Addressing the complexity of biological assay readouts in non-oncology indications and discussing how inflammation, neurodegeneration and other areas challenge traditional screening assays
