Zoran Rankovic

Company: Institute of Cancer Research

Job title: Director & Professor - Chemical Biology & Protein Degradation

Seminars:

Multimodal Screening Strategy for Discovery of Novel Cereblon-Directing Molecular Glue Degraders & Neosubstrates 11:00 am

Molecular Glue Degrader (MGD) discovery mostly relies on screening-based approaches, such as cell viability assays. However, one limitation of such screening methods is the risk of overlooking non-essential neosubstrates of potential therapeutic value To address this risk, we developed a high throughput deep proteomics screening platform utilising label-free, data-independent acquisition mass spectrometry for integrated proteomics…Read more

day: Day 2, Track 1, AM

Workshop B: Enhancing Oral Bioavailability of Bivalent Degraders to Improve Patient Exposure & Maximise Therapeutic Efficacy 1:00 pm - 3:00 pm

The development of PROTACs and other heterobifunctionals holds immense promise for targeted therapies. However, their large molecular size presents significant challenges in achieving oral bioavailability. Traditional methods for ensuring bioavailability, such as the rule of five, do not apply to these larger bifunctional molecules. This workshop will delve into the complexities of making PROTACs orally…Read more

day: Workshop B