Zoran Rankovic
Director & Professor - Chemical Biology & Protein Degradation, Center for Protein Degradation Institute of Cancer Research
Seminars
Wednesday 11th March 2026
Navigating Phenotypic Screening & Biology-First Strategies for Novel Induced Proximity Therapeutics
4:15 pm
- Assessing the strengths, limitations and translational value of phenotypic screening for discovering novel proximity therapeutics
- Comparing biology-first and chemistry-first approaches, and how each guides hit identification, mechanistic validation and modality selection
- Exploring how biology-first strategies and complex disease-relevant assays can unlock non-degrader modalities such as stabilisers, modulators and activators
- Integrating AI-driven modelling and in silico cooperativity prediction with phenotypic and mechanistic workflows to accelerate molecular glue discovery
Tuesday 10th March 2026
Identifying Tractable Targets for Molecular Glues & Moving Beyond Cereblon Chemistry to Recruit Neo-Substrates Against More Indications
2:00 pm
As molecular glue development moves beyond cereblon, this workshop will teach you how to identify tractable ligase–substrate pairs and validate glue activity to unlock new degradation strategies.
We will cover:
- Developing molecular glue discovery platforms to accelerate identification of novel degraders beyond cereblon
- Modelling and validating new ligases to enable degradation of intrinsically disordered proteins (IDPs)
- Applying genetic and phenotypic screening approaches to pinpoint ligases, map degrons, and confirm true glue activity
- Exploring alternative ligase recruitment strategies to overcome G-loop dependency and bind novel neo-substrates
This workshop is ideal for discovery biologists and medicinal chemists expanding
molecular glue development beyond cereblon
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