Bifunctional Degrader Discovery with PROTEINi Screening

Time: 1:45 pm
day: Day 2 Track A PM


  • Performing phenotypic screening for protein degraders using PhoreMost’s PROTEINi technology has identified several novel bio-active degron peptides and their corresponding E3 ligases
  • Harnessing target-specific screening to allow the development of biological bifunctional protein degrader molecules
  • Showcasing how PROTEINi/E3 ligase interaction can be used to inform and accelerate the development of small molecules that interact with E3 ligases and build novel heterobifunctionals