Developing Optimised Folding Interfering Degraders Targeting Cyclin D1
Time: 11:45 am
day: Day 1, Track 2, AM
Details:
- Providing an overview of folding interference as a new modality to induce the degradation of a target protein
- Demonstrating that folding interfering degraders (FIDs) can be optimised to achieve high potency and desirable ADME properties
- Showing in vitro and in vivo characterisation of FIDs acting on Cyclin D1
