Drugging the 14-3-3 Interactome – From Fragments to Cellular Function
Time: 1:30 pm
day: Day 2, Track 1, PM
Details:
- Finding starting points to (selectively) stabilise 14-3-3 protein interactions is strongly aided via dynamic covalent chemistry
- Cooperativity and selectivity are intertwined
- Cellular effects depend strongly on the 14-3-3 clients’ mode of action
