Engineering of Selectivity Between Closely Related Paralogs Via a Novel Molecular Glue Degrader of a Highprofile Epigenetic Target
Time: 11:15 am
day: Day 1, Track A, - AM
Details:
- Monovalent molecular glue degraders for a high-profile epigenetic target were identified using our ligase-agnostic screening platform
- Degrader treatment recapitulates genetic dependencies and affects downstream signalling pathways.
- Molecular dynamics modelling and biochemical validation enabled us to rationalise the determinants of selectivity over closely related proteins and inform chemical optimisation of the molecules
