Harnessing Lysosomal Pathways for Effective Targeted Protein Degradation of Novel Targets to Cure Untreated Diseases
Time: 11:00 am
day: Day 2, Track 2, AM
Details:
- Validating the lysosomal degradation pathway to define its targetable space, similar to the ubiquitination pathway in intracellular degradation
- Designing warheads to engage lysosomal sorting receptors to select novel proteins for degradation and pharmacological benefit
- Expanding the application of lysosomal degradation to different types of extracellular proteins in complex systems and organs to enable tissue specificity
