Introducing a New Modality in Targeted Protein Degradation: Intramolecular Bivalent Glue (IBGs)
Time: 4:45 pm
day: Conference Day Two
Details:
- Exploring mechanistic insights into action of IBGs through bridging protein domains to enhance surface complementarity with E3s
- Using orthogonal genetic screening, biophysical characterisation and structural reconstitution to investigate MOA
- Confirming MOA with measures of ubiquitination and degradation
