Identifying Novel E3 Ligases & Ligands to Create New & Therapeutically Valuable Avenues for Degradation
Time: 8:30 am
day: Pre-Conference Workshop Day
Details:
With CRBN and VHL dominating the TPD landscape, there remains one key question – what of the other 600+ E3 ligases? We are now beginning to develop the tools, techniques, and methodologies to identify, characterize, and validate these ligases and their ligands in a rational, high throughput manner. Identifying the next great ligase will unlock a whole new realm of possibility for treating patients in need.
Attend this Workshop to:
- Identify a new pathway and understand molecular and cellular biology underpinning its potential to be targeted for degradation
- Pinpoint suitable candidate degraders that may be adapted/modified to degrade pathway targets outside of the proteosome
- Select the best existing assays and screening approaches to identify, characterise, and validate a lesser explored pathway or set of potential targets
