Improving PROTAC Selectivity by a Degron Blocking Strategy

Time: 12:15 pm
day: Day 2 Track A AM


  • Harnessing a structural based understanding of where IMiD induced off target degradation derives
  • Spotlighting ligand design strategies to block IMiD-like recruitment of neosubstrates to CRBN
  • Demonstrating proof of concept in the context of a BRD9 PROTAC degrader with enhanced selectivity