Mapping E3 Ligase Binding sites by Photoreactive Fragment Pharmacophores
Time: 4:15 pm
day: Conference Day Two
Details:
- Introducing a new screening concept that combines evolutionary optimized fragment pharmacophores with the use of photoaffinity labelling
- Enabling high hit rates against challenging targets and identifying the binding site by mass spectrometry
- Spotlighting how the performance of the approach is demonstrated against a PPI target, a transcription factor and an E3 ligase
