Revolutionizing Molecular Glue Discovery Through High-Throughput Neomorphic Remodelling of Effector Proteins
Time: 2:15 pm
day: Day 1, Track 1, PM
Details:
- Addressing the bottleneck in induced degradation therapeutics by introducing systematic tools to uncover critical design principles for molecular glue discovery
- Showcasing GlueSEEKER®, a cutting-edge intramolecular editing-based screening platform to precisely remodel E3 ligase surface landscapes for therapeutic innovation
- Demonstrating how re-engineered effector proteins with neomorphic activity expand substrate repertoires, unlocking ideal induced pharmacophores to guide the design of next-generation molecular glues
