Molecular Glues, Better Options Than PROTACs, Parkin Ligase, Parkinson’s Disease & Beyond
Time: 2:45 pm
day: Day 2 Track B PM
Details:
- Exploring how parkin ligase plays a critical role in mitophagy and mitobiogenesis. Mutations in parkin ligase leads to early onset of Parkinson’s disease (PD). The dysfunction of parkin ligase is also attributed to late onset of PD
- Discovering molecular glues that bind parkin, activate parkin function, induce mitophagy in neuronal cells and cardiomyocytes
- Unveiling animal model data suggesting that molecular glues are superior to PROTACs, and easily cross blood brain barriers to have efficacy. Role of parkin in PD and muscle function will be described
