Using Autophagy for Targeted Protein- & Organelle Degradation
Time: 2:15 pm
day: Day 1 Track B PM
Details:
- Expanding the target space of targeted protein degradation by using autophagy (A-TPD)
- An induced-proximity screen was used to identify entry-points to A-TPD for degradation of various cargo
- A heterobifunctional biodegrader was developed that degrades mitochondria by recruitment of an endogenous autophagy cargo receptor
