Multimodal Screening Strategy for Discovery of Novel Cereblon-Directing Molecular Glue Degraders & Neosubstrates
Time: 11:00 am
day: Day 2, Track 1, AM
Details:
- Molecular Glue Degrader (MGD) discovery mostly relies on screening-based approaches, such as cell viability assays. However, one limitation of such screening methods is the risk of overlooking non-essential neosubstrates of potential therapeutic value
- To address this risk, we developed a high throughput deep proteomics screening platform utilising label-free, data-independent acquisition mass spectrometry for integrated proteomics and “ubiquitinomics” analysis
- Screening a diverse subset of our large CRBN-focused library uncovered multiple potent and selective degraders of previously unreported cereblon neosubstrates
