Systematic Discovery of Novel Degraders Through Deep Proteomic Screening
Time: 4:15 pm
day: Day 1, PM
Details:
- High-throughput proteomics rapidly establishes broad pipelines of novel, high-value degrader targets at scale and within native cells, employing a target- and E3 ligase-unbiased approach
- It facilitates the identification of novel degrader targets, monitoring of proteome-wide selectivity, and detection of molecules acting through new E3 ligases and emerging TPD mechanisms
- Global ubiquitinomics reveals degrader-induced modifications at an unprecedented depth of 50,000 ubiquitination sites, while cellular proximity labeling detects degrader-induced intracellular complex formation at high throughput
