Lessons From in-solution Structural Dynamics for the Design of CRBN Ligands
Time: 1:45 pm
day: Day 1 Track A PM
Details:
- Harnessing solution NMR to reveal how ligand binding gradually induces the folding of the thalidomide binding domain (TBD)
- Highlighting key criteria for ligands to induce folding for efficient molecular glue (MG) activity
- Discussing potential differences in the design criteria of CRBN ligands for MGs and/or PROTACs
