Koichi Ito

Company: Prelude Therapeutics​

Job title: Senior Director, Biology

Seminars:

Bridging Pharmacokinetics & Pharmacodynamics to Enhance the Pre-Clinical Efficacy of Degrader-Loaded ADCs Targeting SMARCA &CDK9 for Drug Development Optimisation 11:15 am

Exploring the pharmacokinetic and pharmacodynamic challenges unique to SMARCA and CDK9 targets, focusing on degradation thresholds required to maximise therapeutic efficacy Examining the role of linker stability and release mechanisms in ADCs carrying degrader payloads, aiming to achieve controlled, targeted delivery of degraders to tumour cells Assessing how linker and payload characteristics influence absorption, distribution,…Read more

day: Day 1, Track 2, AM

Workshop B: Enhancing Oral Bioavailability of Bivalent Degraders to Improve Patient Exposure & Maximise Therapeutic Efficacy 1:00 pm - 3:00 pm

The development of PROTACs and other heterobifunctionals holds immense promise for targeted therapies. However, their large molecular size presents significant challenges in achieving oral bioavailability. Traditional methods for ensuring bioavailability, such as the rule of five, do not apply to these larger bifunctional molecules. This workshop will delve into the complexities of making PROTACs orally…Read more

day: Workshop B