Matthias Brand

Company: Proxygen

Job title: Chief Scientific Officer

Seminars:

PANEL DISCUSSION Clear Skies or Stormy Seas: Sailing the European Markets in Search of Funding & Partnerships for Effective Degrader Development 8:45 am

What are the trends in the current European investment environment, and how can emerging companies effectively demonstrate commercial viability in these conditions? What is the average European life sciences VC’s risk appetite, and how can biotechs navigate this to secure investment? How do the dynamics of biotech-to-biotech deals compare to pharma partnerships? Does Europe need…Read more

day: Day Two Until 10am

Engineering of Selectivity Between Closely Related Paralogs Via a Novel Molecular Glue Degrader of a Highprofile Epigenetic Target 11:15 am

Monovalent molecular glue degraders for a high-profile epigenetic target were identified using our ligase-agnostic screening platform Degrader treatment recapitulates genetic dependencies and affects downstream signalling pathways. Molecular dynamics modelling and biochemical validation enabled us to rationalise the determinants of selectivity over closely related proteins and inform chemical optimisation of the moleculesRead more

day: Day 1, Track A, - AM