Rick Ewing

Company: Rapafusyn Pharmaceuticals

Job title: Vice President & Head of Chemistry

Seminars:

Non-Degrading Molecular Glues: A Platform for Finding Novel Chemical Matter for Inhibiting Intracellular & Transmembrane Proteins 1:00 pm

The described macrocycles form ternary complexes comprising a presenter protein (FKBP12), the molecular glue, and a target protein. Inhibition through formation of a ternary complex often results in potency, selectivity over homologous proteins and favourable drug like properties such as slow binding kinetics The principles of constructing DEL libraries with Topological diversity is a key…Read more

day: Day 2, Track 2, PM

ROUNDTABLE DISCUSSION Discussing Non-Degrading Induced Proximity Therapeutics & Transferable Learnings to & From Degraders 1:30 pm

How can we measure and optimise cooperativity in induced proximity therapeutics, including PROTACs and non-degraders? What strategies are most effective for interrogating targets to determine their sensitivity and compatibility with your induced proximity platforms? In what ways do finding starting chemical matter differ for non-degrading induced proximity therapeutics from those for degraders?Read more

day: Day 2, Track 2, PM