Zhangping Xiao

Company: Imperial College London

Job title: Marie Curie Fellow Postdoc, Tate Group

Seminars:

Advancing PROTAC Discovery Through SLIP: Identifying Degradation Effector Sites for Targeted Therapeutics 3:45 pm

Addressing the need for more TPD effectors and their ligands to expand the therapeutic potential of protein degradation Introducing SLIP, a cutting-edge platform that enables the creation of proximity in live cells, enhancing the discovery of new degradation pathways Demonstrating how SLIP has successfully identified PROTAC-able sites on key TPD effectors, paving the way for…Read more

day: Day 1, PM

Novel E3 Ligase-Based Targeted Protein Degradation: Potential Applications Within & Beyond Cancer Therapy 4:45 pm

Somatic mutation of some E3 ligases create novel E3 ligase that do not exist in normal tissues Targeted protein degradation using the mutated E3 ligases are very specific and only happen with the presence of the mutated E3 ligase Novel E3-based TPD and potential applications are discussed with an exampleRead more

day: Day 1, PM