Unveiling Basal Protein-Protein Interactions to Drive Molecular Glue Discovery Across 200 Therapeutic Targets
Time: 1:45 pm
day: Day 1, Track 1, PM
Details:
- Mapping over 500 basal protein-protein interactions between therapeutic targets and a diverse range of ligases and chaperone proteins to uncover novel degradation opportunities
- Employing site-directed mutagenesis to characterize protein-protein interaction interfaces, enabling a deeper understanding of structural determinants for affinity modulation
- Prioritizing key interactions to inform small molecule discovery campaigns, accelerating the identification of molecular glues with high therapeutic potential
