A Tricycle Journey to in-vivo Degraders of the Oncogenic Transcription Factor BCL6
Time: 12:15 pm
day: Day 1 Track B AM
Details:
- BCL6 is an oncogenic transcriptional repressor upregulated in a large fraction of diffuse large B cell lymphomas (DLBCL)
- We discovered potent BCL6 inhibitors. Some inhibitors triggered degradation of BCL6.
- We elucidated the structural requirements for degradation enabling the discovery of a potent in vivo degrader of BCL6
